Transdermal active drug delivery is one way to propose new disease treatment as an improvement to passive patches diffusion based on concentration gradient. Although skin limitations due to low permeability active transdermal delivery approach are investigated, by the proposition of an iontophoretic reusable and controllable patch. Making such an e-health care device offers active control and permanent actuating link able to control the amount of drug delivered. In vitro experiment is conducted to investigate the current effect on the permeation. Modelling and simulations are carried out to optimise the design and the electrical stimulation and finally a global overview of the architecture of the patch is presented.