%0 Conference Paper %F Oral %T Label-free discrimination of human lymphoma cell sub-populations with microwave dielectric spectroscopy %+ Équipe Micro et nanosystèmes HyperFréquences Fluidiques (LAAS-MH2F) %+ Centre de Recherches en Cancérologie de Toulouse (CRCT) %A Grenier, Katia %A Artis, François %A Poupot, Mary %A Fournié, J-J %A Dubuc, David %< avec comité de lecture %Z Rapport LAAS n° 18446 %B IEEE International Microwave Symposium (IMS 2018) %C Philadelphie, PA, United States %P 4p. %8 2018-06-10 %D 2018 %K biological cells %K biosensor %K lymphoma %K permittivity %K sub-populations %K Microwave dielectric spectroscopy %Z Engineering Sciences [physics]/Electromagnetism %Z Engineering Sciences [physics]/Micro and nanotechnologies/Microelectronics %Z Life Sciences [q-bio]/Bioengineering/ImagingConference papers %X This paper deals with the label-free microwave die-lectric characterization of B lymphoma cell lines, the OCI-LY7, OCI-LY10 and OCI-LY18 ones, and demonstrates that the technique is able to discriminate these three sub-population cell lines with their different dielectric properties. Proof is given that such a differentiation is not due to a variation of cell size, viability or cells concentration, but to internal molecular differences. This constitutes a major result as it demonstrates for the first time that microwave dielectric spectroscopy is sufficiently sensitive using di-electric properties variations to distinguish very similar biological cell lines of the same phenotype, B lymphoma cell lines in our case, whereas such a detection is traditionally performed with marker-based and costly equipment or using heavy genetic methods. %G English %2 https://laas.hal.science/hal-01951446/document %2 https://laas.hal.science/hal-01951446/file/IMS2018-lymphomes-final.pdf %L hal-01951446 %U https://laas.hal.science/hal-01951446 %~ UNIV-TLSE2 %~ UNIV-TLSE3 %~ CNRS %~ INSA-TOULOUSE %~ LAAS %~ UT1-CAPITOLE %~ LAAS-MH2F %~ LAAS-MICRO-NANO-BIO-TECHNOLOGIES %~ INSA-GROUPE %~ TOULOUSE-INP %~ UNIV-UT3 %~ UT3-INP %~ UT3-TOULOUSEINP %~ CRCT