<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-02080026</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-03T01:21:32+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Investigating the Formation of Structural Elements in Proteins Using Local Sequence-Dependent Information and a Heuristic Search Algorithm</title>
            <author role="aut">
              <persName>
                <forename type="first">Alejandro</forename>
                <forename type="middle">N</forename>
                <surname>Estaña</surname>
              </persName>
              <idno type="halauthorid">1076553-0</idno>
              <affiliation ref="#struct-59411"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Malik</forename>
                <surname>Ghallab</surname>
              </persName>
              <email type="md5">64ea7c3632d292573f1d5a79a3d022c8</email>
              <email type="domain">laas.fr</email>
              <idno type="idhal" notation="string">mghallab</idno>
              <idno type="idhal" notation="numeric">9204</idno>
              <idno type="halauthorid" notation="string">3696-9204</idno>
              <idno type="IDREF">https://www.idref.fr/058551662</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-4326-049X</idno>
              <orgName ref="#struct-392741"/>
              <affiliation ref="#struct-392741"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Pau</forename>
                <surname>Bernadó</surname>
              </persName>
              <email type="md5">1e88825e21e9ef84c5eb9ceec5a36c32</email>
              <email type="domain">irbbarcelona.org</email>
              <idno type="idhal" notation="numeric">771161</idno>
              <idno type="halauthorid" notation="string">778180-771161</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-7395-5922</idno>
              <idno type="IDREF">https://www.idref.fr/199227071</idno>
              <affiliation ref="#struct-59411"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Juan</forename>
                <surname>Cortés</surname>
              </persName>
              <email type="md5">0f6f22d31c6ee9d1a2ba6235ef08c274</email>
              <email type="domain">laas.fr</email>
              <idno type="idhal" notation="string">juan-cortes</idno>
              <idno type="idhal" notation="numeric">3712</idno>
              <idno type="halauthorid" notation="string">22673-3712</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/F-7545-2019</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-4660-0306</idno>
              <idno type="IDREF">https://www.idref.fr/07673658X</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/F-7545-2019</idno>
              <orgName ref="#struct-392741"/>
              <affiliation ref="#struct-392741"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Juan</forename>
                <surname>Cortés</surname>
              </persName>
              <email type="md5">0f6f22d31c6ee9d1a2ba6235ef08c274</email>
              <email type="domain">laas.fr</email>
            </editor>
            <funder ref="#projanr-50581"/>
            <funder ref="#projanr-37832"/>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2019-03-26 14:10:03</date>
              <date type="whenModified">2025-10-22 18:04:08</date>
              <date type="whenReleased">2019-04-03 15:00:21</date>
              <date type="whenProduced">2019-03</date>
              <date type="whenEndEmbargoed">2019-03-26</date>
              <ref type="file" target="https://laas.hal.science/hal-02080026v1/document">
                <date notBefore="2019-03-26"/>
              </ref>
              <ref type="file" subtype="greenPublisher" n="1" target="https://laas.hal.science/hal-02080026v1/file/Estana_MDPI-Molecules_2019.pdf" id="file-2080026-2087864">
                <date notBefore="2019-03-26"/>
              </ref>
              <ref type="annex" n="0" target="https://laas.hal.science/hal-02080026v1/file/molecules-440900_SI.pdf" id="file-2080026-2087865">
                <date notBefore="2019-03-26"/>
              </ref>
              <ref type="externalLink" target="https://www.mdpi.com/1420-3049/24/6/1150/pdf"/>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="167638">
                <persName>
                  <forename>Juan</forename>
                  <surname>Cortés</surname>
                </persName>
                <email type="md5">0f6f22d31c6ee9d1a2ba6235ef08c274</email>
                <email type="domain">laas.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-02080026</idno>
            <idno type="halUri">https://laas.hal.science/hal-02080026</idno>
            <idno type="halBibtex">estana:hal-02080026</idno>
            <idno type="halRefHtml">&lt;i&gt;Molecules&lt;/i&gt;, 2019, 24 (6), pp.1150. &lt;a target="_blank" href="https://dx.doi.org/10.3390/molecules24061150"&gt;&amp;#x27E8;10.3390/molecules24061150&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Molecules, 2019, 24 (6), pp.1150. &amp;#x27E8;10.3390/molecules24061150&amp;#x27E9;</idno>
            <availability status="restricted">
              <licence target="https://about.hal.science/hal-authorisation-v1/">HAL Authorization<ref corresp="#file-2080026-2087864"/><ref corresp="#file-2080026-2087865"/></licence>
            </availability>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="UNIV-TLSE2">Université Toulouse 2</idno>
            <idno type="stamp" n="UNIV-TLSE3">Université de Toulouse</idno>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="INSA-TOULOUSE">Institut National des Sciences Appliquées de Toulouse</idno>
            <idno type="stamp" n="LAAS">Laboratoire d'analyse et d'architecture des systèmes</idno>
            <idno type="stamp" n="CBS">Centre de biochimie structurale</idno>
            <idno type="stamp" n="UT1-CAPITOLE">Université Toulouse 1 Capitole</idno>
            <idno type="stamp" n="LAAS-RIS" corresp="LAAS-ROBOTIQUE">Équipe Robotique et InteractionS</idno>
            <idno type="stamp" n="LAAS-ROBOTIQUE" corresp="LAAS">LAAS-Robotique</idno>
            <idno type="stamp" n="TDS-MACS">Réseau de recherche en Théorie des Systèmes Distribués, Modélisation, Analyse et Contrôle des Systèmes</idno>
            <idno type="stamp" n="BS">Biologie-Santé</idno>
            <idno type="stamp" n="UNIV-MONTPELLIER">Université de Montpellier</idno>
            <idno type="stamp" n="INSA-GROUPE">Groupe INSA</idno>
            <idno type="stamp" n="ANR">ANR</idno>
            <idno type="stamp" n="TOULOUSE-INP">Toulouse - INP</idno>
            <idno type="stamp" n="UNIV-UT3">Université Toulouse 3</idno>
            <idno type="stamp" n="UT3-INP">Université de Toulouse / Toulouse INP</idno>
            <idno type="stamp" n="UT3-TOULOUSEINP">Université de Toulouse / Toulouse INP</idno>
            <idno type="stamp" n="UM-2015-2021" corresp="UNIV-MONTPELLIER">Université de Montpellier (2015-2021)</idno>
            <idno type="stamp" n="IA">Intelligence Artificielle</idno>
            <idno type="stamp" n="TEST7-HALCNRS">test 7 du portail hal cnrs</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="invited" n="0">No</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Investigating the Formation of Structural Elements in Proteins Using Local Sequence-Dependent Information and a Heuristic Search Algorithm</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Alejandro</forename>
                    <forename type="middle">N</forename>
                    <surname>Estaña</surname>
                  </persName>
                  <idno type="halauthorid">1076553-0</idno>
                  <affiliation ref="#struct-59411"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Malik</forename>
                    <surname>Ghallab</surname>
                  </persName>
                  <email type="md5">64ea7c3632d292573f1d5a79a3d022c8</email>
                  <email type="domain">laas.fr</email>
                  <idno type="idhal" notation="string">mghallab</idno>
                  <idno type="idhal" notation="numeric">9204</idno>
                  <idno type="halauthorid" notation="string">3696-9204</idno>
                  <idno type="IDREF">https://www.idref.fr/058551662</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-4326-049X</idno>
                  <orgName ref="#struct-392741"/>
                  <affiliation ref="#struct-392741"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Pau</forename>
                    <surname>Bernadó</surname>
                  </persName>
                  <email type="md5">1e88825e21e9ef84c5eb9ceec5a36c32</email>
                  <email type="domain">irbbarcelona.org</email>
                  <idno type="idhal" notation="numeric">771161</idno>
                  <idno type="halauthorid" notation="string">778180-771161</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-7395-5922</idno>
                  <idno type="IDREF">https://www.idref.fr/199227071</idno>
                  <affiliation ref="#struct-59411"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Juan</forename>
                    <surname>Cortés</surname>
                  </persName>
                  <email type="md5">0f6f22d31c6ee9d1a2ba6235ef08c274</email>
                  <email type="domain">laas.fr</email>
                  <idno type="idhal" notation="string">juan-cortes</idno>
                  <idno type="idhal" notation="numeric">3712</idno>
                  <idno type="halauthorid" notation="string">22673-3712</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/F-7545-2019</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-4660-0306</idno>
                  <idno type="IDREF">https://www.idref.fr/07673658X</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/F-7545-2019</idno>
                  <orgName ref="#struct-392741"/>
                  <affiliation ref="#struct-392741"/>
                </author>
              </analytic>
              <monogr>
                <idno type="localRef">Rapport LAAS n° 19110</idno>
                <idno type="halJournalId" status="VALID">17196</idno>
                <idno type="issn">1420-3049</idno>
                <title level="j">Molecules</title>
                <imprint>
                  <publisher>MDPI</publisher>
                  <biblScope unit="volume">24</biblScope>
                  <biblScope unit="issue">6</biblScope>
                  <biblScope unit="pp">1150</biblScope>
                  <date type="datePub">2019-03</date>
                </imprint>
              </monogr>
              <idno type="doi">10.3390/molecules24061150</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <keywords scheme="author">
                <term xml:lang="en">proteins</term>
                <term xml:lang="en">structural elements</term>
                <term xml:lang="en">conformational transitions</term>
                <term xml:lang="en">structural database</term>
                <term xml:lang="en">heuristic</term>
              </keywords>
              <classCode scheme="halDomain" n="info.info-rb">Computer Science [cs]/Robotics [cs.RO]</classCode>
              <classCode scheme="halDomain" n="info.info-mo">Computer Science [cs]/Modeling and Simulation</classCode>
              <classCode scheme="halDomain" n="info.info-ai">Computer Science [cs]/Artificial Intelligence [cs.AI]</classCode>
              <classCode scheme="halDomain" n="info.info-bi">Computer Science [cs]/Bioinformatics [q-bio.QM]</classCode>
              <classCode scheme="halDomain" n="sdv.bbm.bc">Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM]</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>Structural elements inserted in proteins are essential to define folding/unfolding 1 mechanisms and partner recognition events governing signaling processes in living organisms. 2 Here, we present an original approach to model the folding mechanism of these structural elements. 3 Our approach is based on the exploitation of local, sequence-dependent structural information 4 encoded in a database of three-residue fragments extracted from a large set of high-resolution 5 experimentally determined protein structures. The computation of conformational transitions leading 6 to the formation of the structural elements is formulated as a discrete path search problem using this 7 database. To solve this problem, we propose a heuristically-guided depth-first search algorithm. The 8 domain-dependent heuristic function aims at minimizing the length of the path in terms of angular 9 distances, while maximizing the local density of the intermediate states, which is related to their 10 probability of existence. We have applied the strategy to two small synthetic polypeptides mimicking 11 two common structural motifs in proteins. The folding mechanisms extracted are very similar to 12 those obtained when using traditional, computationally expensive approaches. These results show 13 that the proposed approach, thanks to its simplicity and computational efficiency, is a promising 14 research direction. 15</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="laboratory" xml:id="struct-59411" status="OLD">
          <idno type="ISNI">0000000406391954</idno>
          <idno type="RNSR">200717455X</idno>
          <idno type="ROR">https://ror.org/0189yvq06</idno>
          <orgName>Centre de Biochimie Structurale [Montpellier]</orgName>
          <orgName type="acronym">CBS</orgName>
          <date type="start">1999-01-01</date>
          <date type="end">2021-12-31</date>
          <desc>
            <address>
              <addrLine>29 rue de Navacelles 34090 Montpellier Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.cbs.cnrs.fr/</ref>
          </desc>
          <listRelation>
            <relation name="U1054" active="#struct-303623" type="direct"/>
            <relation active="#struct-410122" type="direct"/>
            <relation name="UMR5048" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="researchteam" xml:id="struct-392741" status="OLD">
          <orgName>Équipe Robotique et InteractionS</orgName>
          <orgName type="acronym">LAAS-RIS</orgName>
          <date type="end">2025-01-01</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.laas.fr/public/fr/ris</ref>
          </desc>
          <listRelation>
            <relation active="#struct-459" type="direct"/>
            <relation active="#struct-81148" type="indirect"/>
            <relation name="443875" active="#struct-443875" type="indirect"/>
            <relation active="#struct-116255" type="indirect"/>
            <relation active="#struct-301232" type="indirect"/>
            <relation active="#struct-443875" type="indirect"/>
            <relation active="#struct-116256" type="indirect"/>
            <relation active="#struct-217752" type="indirect"/>
            <relation name="UPR8001" active="#struct-441569" type="indirect"/>
            <relation active="#struct-448187" type="indirect"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-303623" status="VALID">
          <idno type="IdRef">026388278</idno>
          <idno type="ROR">https://ror.org/02vjkv261</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>
            <address>
              <addrLine>101, rue de Tolbiac, 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-410122" status="OLD">
          <idno type="ISNI">0000000120970141</idno>
          <idno type="ROR">https://ror.org/051escj72</idno>
          <orgName>Université de Montpellier</orgName>
          <orgName type="acronym">UM</orgName>
          <date type="end">2021-12-31</date>
          <desc>
            <address>
              <addrLine>163 rue Auguste Broussonnet - 34090 Montpellier</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.umontpellier.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-441569" status="VALID">
          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <idno type="ROR">https://ror.org/02feahw73</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cnrs.fr/</ref>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-459" status="OLD">
          <idno type="IdRef">199278792</idno>
          <idno type="ISNI">0000 0001 2188 216X </idno>
          <idno type="RNSR">199517454Y</idno>
          <idno type="ROR">https://ror.org/03vcm6439</idno>
          <orgName>Laboratoire d'analyse et d'architecture des systèmes</orgName>
          <orgName type="acronym">LAAS</orgName>
          <date type="start">1968-01-01</date>
          <date type="end">2025-01-01</date>
          <desc>
            <address>
              <addrLine>7 Av du colonel Roche 31077 TOULOUSE CEDEX 4</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.laas.fr</ref>
          </desc>
          <listRelation>
            <relation active="#struct-81148" type="direct"/>
            <relation name="443875" active="#struct-443875" type="indirect"/>
            <relation active="#struct-116255" type="direct"/>
            <relation active="#struct-301232" type="indirect"/>
            <relation active="#struct-443875" type="indirect"/>
            <relation active="#struct-116256" type="direct"/>
            <relation active="#struct-217752" type="direct"/>
            <relation name="UPR8001" active="#struct-441569" type="direct"/>
            <relation active="#struct-448187" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-81148" status="VALID">
          <idno type="IdRef">026404354</idno>
          <idno type="ISNI">0000000121902837</idno>
          <idno type="ROR">https://ror.org/0443n9e75</idno>
          <orgName>Université Toulouse Capitole</orgName>
          <orgName type="acronym">UT Capitole</orgName>
          <date type="start">1970-01-01</date>
          <desc>
            <address>
              <addrLine>2 rue du Doyen-Gabriel-Marty - 31042 Toulouse Cedex 9</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.ut-capitole.fr/</ref>
          </desc>
          <listRelation>
            <relation name="443875" active="#struct-443875" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-443875" status="VALID">
          <idno type="ROR">https://ror.org/017tgbk05</idno>
          <orgName>Communauté d'universités et établissements de Toulouse</orgName>
          <orgName type="acronym">Comue de Toulouse</orgName>
          <desc>
            <address>
              <addrLine>41 Allée Jules Guesde, 31000 Toulouse</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.univ-toulouse.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-116255" status="VALID">
          <idno type="IdRef">026388766</idno>
          <idno type="ISNI">0000 0001 2286 8343</idno>
          <idno type="ROR">https://ror.org/01h8pf755</idno>
          <idno type="Wikidata">Q858979</idno>
          <orgName>Institut National des Sciences Appliquées - Toulouse</orgName>
          <orgName type="acronym">INSA Toulouse</orgName>
          <date type="start">1963-10-21</date>
          <desc>
            <address>
              <addrLine>135, avenue de Rangueil - 31077 Toulouse cedex 4</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.insa-toulouse.fr</ref>
          </desc>
          <listRelation>
            <relation active="#struct-301232" type="direct"/>
            <relation active="#struct-443875" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-301232" status="VALID">
          <idno type="IdRef">162105150</idno>
          <orgName>Institut National des Sciences Appliquées</orgName>
          <orgName type="acronym">INSA</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="institution" xml:id="struct-116256" status="VALID">
          <idno type="IdRef">026403994</idno>
          <idno type="ROR">https://ror.org/04ezk3x31</idno>
          <orgName>Université Toulouse - Jean Jaurès</orgName>
          <orgName type="acronym">UT2J</orgName>
          <date type="start">1971-01-01</date>
          <desc>
            <address>
              <addrLine>5 allées Antonio Machado - 31058 Toulouse Cedex 9</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-tlse2.fr</ref>
          </desc>
          <listRelation>
            <relation active="#struct-443875" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-217752" status="OLD">
          <idno type="IdRef">026404672</idno>
          <idno type="ISNI">0000000121617331</idno>
          <idno type="ROR">https://ror.org/02v6kpv12</idno>
          <idno type="Wikidata">Q1273188</idno>
          <orgName>Université Toulouse III - Paul Sabatier</orgName>
          <orgName type="acronym">UT3</orgName>
          <date type="end">2025-01-01</date>
          <desc>
            <address>
              <addrLine>118 route de Narbonne - 31062 Toulouse</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-tlse3.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-443875" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-448187" status="VALID">
          <idno type="IdRef">026388820</idno>
          <idno type="ISNI">0000000121766169</idno>
          <idno type="ROR">https://ror.org/033p9g875</idno>
          <orgName>Institut National Polytechnique (Toulouse)</orgName>
          <orgName type="acronym">Toulouse INP</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.inp-toulouse.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-443875" type="direct"/>
          </listRelation>
        </org>
      </listOrg>
      <listOrg type="projects">
        <org type="anrProject" xml:id="projanr-50581" status="VALID">
          <idno type="anr">ANR-10-INBS-0005</idno>
          <orgName>FRISBI</orgName>
          <desc>Infrastructure Française pour la Biologie Structurale Intégrée</desc>
          <date type="start">2010</date>
        </org>
        <org type="anrProject" xml:id="projanr-37832" status="VALID">
          <idno type="anr">ANR-10-LABX-0012</idno>
          <idno type="program">Laboratoires d'excellence</idno>
          <orgName>EpiGenMed</orgName>
          <desc>From Genome and Epigenome to Molecular Medicine: turning new paradigms in biology into the therapeutic strategies of tomorrow</desc>
          <date type="start">2010</date>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>