The 2018 2nd International Workshop on Context-aware, Autonomous and Smart Architectures (CASA 2018) was held in conjunction with the 12th European Conference on Software Architecture (ECSA 2018), on September, 24th, 2018 in Madrid, Spain. The main topic of the workshop concerned the design of software architectures for dynamic, autonomous, and adaptive context-aware smart systems. Such systems address changes and cope with uncertainties at runtime. Therefore, the software architecture of such system should ensure the basis for their dynamicity, adaptivity, and autonomy. These basis should be solid because they represent the backbone of a system, and in the same time flexible because they address dynamicity during execution. The one-day workshop aimed to bring together researchers and practitioners from the academic and the industrial world to share and discuss their approaches, solutions, methodologies, ideas, and open questions about the software architecture design for context-aware, autonomous, and smart systems. The workshop enabled discussions and put the basis for future collaborations among the participants.