In recent years, it has been reported that adding titanium into reactive thermite composites (such as Al/I 2 O 5 , B/CuO) can improve their combustion efficiency and lower their ignition temperature. However, these authors were only able to point out the complexity of the mechanisms governing ternary thermites reactivity but failed to answer the question of the exact role of the Ti reaction with oxidizers in such thermite composites. Due to the fast reaction rate and the difficulties in tracking elemental movements in Ti-based thermite nanoparticles, a full diagnosis from a fundamental standpoint awaits. In this work [1], we put our focus on in-depth understanding the reaction mechanism of Ti-based thermite by employing magnetron-sputtering technique to grow high purity and well-defined CuO/Ti nanolaminates. Contrary to powdered nanothermites in which a thick titania oxide shell layer separates its pure fuel Ti core from the outer surface oxidizer particle, nanolaminates feature a very well controlled interface (in thickness and structure) between the fuel and oxidizer. Furthermore, the multilayer system allows a full contact between the different species compared to particulate system showing random contact, which is crucial to clearly identify and rationalize the different mechanisms taking place during initiation/propagation of the reaction. This provides an ideal model-system to quantitatively describe the TiOx interfacial oxide growing using a host of characterization techniques including microscopy, thermal analysis, spectroscopy and X-ray diffractometric.