Advancing Cardiomyocyte Maturation: Current Strategies and Promising Conductive Polymer‐Based Approaches - LAAS - Laboratoire d'Analyse et d'Architecture des Systèmes Accéder directement au contenu
Article Dans Une Revue Advanced Healthcare Materials Année : 2024

Advancing Cardiomyocyte Maturation: Current Strategies and Promising Conductive Polymer‐Based Approaches

Résumé

Abstract Cardiovascular diseases are a leading cause of mortality and pose a significant burden on healthcare systems worldwide. Despite remarkable progress in medical research, the development of effective cardiovascular drugs has been hindered by high failure rates and escalating costs. One contributing factor is the limited availability of mature cardiomyocytes (CMs) for accurate disease modeling and drug screening. Human induced pluripotent stem cell‐derived CMs offer a promising source of CMs; however, their immature phenotype presents challenges in translational applications. This review focuses on the road to achieving mature CMs by summarizing the major differences between immature and mature CMs, discussing the importance of adult‐like CMs for drug discovery, highlighting the limitations of current strategies, and exploring potential solutions using electro‐mechano active polymer‐based scaffolds based on conductive polymers. However, critical considerations such as the trade‐off between 3D systems and nutrient exchange, biocompatibility, degradation, cell adhesion, longevity, and integration into wider systems must be carefully evaluated. Continued advancements in these areas will contribute to a better understanding of cardiac diseases, improved drug discovery, and the development of personalized treatment strategies for patients with cardiovascular disorders.
Fichier principal
Vignette du fichier
Adv Healthcare Materials - 2024 - Elkhoury - Advancing Cardiomyocyte Maturation Current Strategies and Promising.pdf (3.88 Mo) Télécharger le fichier
Origine : Publication financée par une institution
Licence : CC BY - Paternité

Dates et versions

hal-04484428 , version 1 (29-02-2024)

Licence

Paternité

Identifiants

Citer

Kamil Elkhoury, Sacha Kodeih, Eduardo Enciso-Martínez, Ali Maziz, Christian Bergaud. Advancing Cardiomyocyte Maturation: Current Strategies and Promising Conductive Polymer‐Based Approaches. Advanced Healthcare Materials, inPress, ⟨10.1002/adhm.202303288⟩. ⟨hal-04484428⟩
4 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More