DNA Sizing with pg/μL Sensitivity for Cell-Free DNA Analysis with the μLAS Technology - LAAS - Laboratoire d'Analyse et d'Architecture des Systèmes
Chapitre D'ouvrage Année : 2024

DNA Sizing with pg/μL Sensitivity for Cell-Free DNA Analysis with the μLAS Technology

Résumé

The µLAS technology enables in-line DNA concentration and separation in a microchannel. Here, we describe its operation to analyze the size profile of cell-free DNA (cfDNA) extracted from blood plasma. Operated on commercial systems for capillary electrophoresis, we provide the size distribution of healthy individuals or patients using an input of 10 µL.
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Dates et versions

hal-04783449 , version 1 (14-11-2024)

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Audrey Boutonnet, Inga Tijunelyte, Aurélien Bancaud, Frédéric Ginot. DNA Sizing with pg/μL Sensitivity for Cell-Free DNA Analysis with the μLAS Technology. Microfluidics Diagnostics, 2804, Springer US, pp.53-64, 2024, Methods in Molecular Biology, ⟨10.1007/978-1-0716-3850-7_2⟩. ⟨hal-04783449⟩
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