Article Dans Une Revue npj Biological Physics and Mechanics Année : 2025

Spatial confinement and life under pressure from physiology to pathology

Résumé

Tree roots sprouting into the ground or tumors proliferating within an organ are a few examples of proliferation under spatial confinement, which leads to growth-induced pressure. This compressive mechanical stress can impact a plethora of processes in all organisms. In this review, I will discuss the physiological and pathological consequences of spatial confinement in plants, microbes and animal cells, and will discuss in more depth the case of solid tumors.

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hal-05244640 , version 1 (08-09-2025)

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Morgan Delarue. Spatial confinement and life under pressure from physiology to pathology. npj Biological Physics and Mechanics, 2025, 2 (1), pp.8. ⟨10.1038/s44341-025-00013-7⟩. ⟨hal-05244640⟩
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