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Journal Articles MRS Communications Year : 2017

Colon cancer cells adhesion on polymeric nanostructured surfaces

Abstract

In this work, we report on the adhesion of HCT116 (human colon carcinoma cells) cultured on nanofibrillar polymethylmethacrylate (PMMA) and SU-8 micropillars substrates. Both surfaces enabled a good cell proliferation and promoted the formation of adherent interconnections with the fabricated nano- and microstructures. The three-dimensional immunofluorescence confocal characterization of the cells on nanotextured PMMA highlighted the expression of well-spread F-actin cytoskeletal networks as well as the presence of focal adhesions. This study provides thus interesting perspectives for further investigations on the force/adhesion mechanisms related to cancer cell growth and proliferation.

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Biomaterials
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Dates and versions

hal-01675463 , version 1 (04-01-2018)

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Angelo Accardo, Victoria Shalabaeva, Rosanna La Rocca. Colon cancer cells adhesion on polymeric nanostructured surfaces. MRS Communications, 2017, pp.1 - 5. ⟨10.1557/mrc.2017.128⟩. ⟨hal-01675463⟩
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