Energy storage systems (ESSs) can enhance the performance of energy networks in multiple ways; they can compensate the stochastic nature of renewable energies and support their large-scale integration into the grid environment. Energy storage options can also be used for economic operation of energy systems to cut down system’s operating cost. By utilizing ESSs, it is very possible to store energy in off-peak hours with lower cost and energize the grid during peak load intervals avoiding high price spikes. Application of ESSs will also enable better utilization of distributed energy sources and provide higher controllability at supply/demand side which is helpful for load leveling or peak shaving purposes. Last but not least, ESSs can provide frequency regulation services in off-grid locations where there is a strong need to meet the power balance in different operating conditions. Each of the abovementioned applications of energy storage units requires certain performance measures and constraints, which has to be well considered in design phase and embedded in control and management strategies. This chapter mainly focuses on these aspects and provides a general framework for optimal design and operation management of battery-based ESSs in energy networks.