This paper deals with a control strategy for a DC-DC quadratic boost converter. In particular, a hybrid control scheme is proposed to encompass a control law and an observer for the estimation of the system states, based only on the measurements of the input and output voltages. Differently from classical control methods, where the controller is designed from a small-signal model, here the real model of the system is examined without considering the average values of the discrete variables. Using hybrid dynamical system theory, asymptotic stability of a neighborhood of the equilibrium point is established, ensuring practical stability of the origin, which contains estimation and tracking errors. Experimental results show the effectiveness of the proposed approach.