Microwave Microfabricated Sensor Dedicated to the Dielectric Characterization of Biological Microtissues - LAAS - Laboratoire d'Analyse et d'Architecture des Systèmes Access content directly
Conference Papers Year : 2022

Microwave Microfabricated Sensor Dedicated to the Dielectric Characterization of Biological Microtissues

Abstract

Microwave dielectric spectroscopy is a promising technique that allows intracellular, non-invasive, label-free and cost-effective biological studies. To complement the sensing possibilities of this technique at this frequency range, which have been previously demonstrated at the single cell, cellular suspensions and organs levels, a microwave-based sensor is designed, fabricated and evaluated to dielectrically characterize 3D biological microtissues. Such a biological model is indeed of high interest for biological investigations, as it constitutes an intermediate entity between 2D cell cultures and organs, exhibiting a biological response close to the one obtained with tissue physiology. The proposed sensor here the development of one of the first microfabricated device for spheroids studies. A discussion on the way of analyzing the data is proposed thanks the measurements of different fixed spheroids and polystyrene beads.
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Dates and versions

hal-03713832 , version 1 (05-07-2022)

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Olivia Peytral-Rieu, David Dubuc, Katia Grenier. Microwave Microfabricated Sensor Dedicated to the Dielectric Characterization of Biological Microtissues. 2022 3rd URSI Atlantic and Asia Pacific Radio Science Meeting (AT-AP-RASC), May 2022, Gran Canaria, Spain. ⟨10.23919/AT-AP-RASC54737.2022.9814189⟩. ⟨hal-03713832⟩
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